Corrosive Liquid and Dalton

Dosing and Administration of drugs: powder vial. The main pharmaco-therapeutic effects of drugs: imidazotetrazyn alkiluvalnyy means of antitumor activity, with getting into the systemic circulation undergoes rapid chemical conversion to form active compound - MTIK; MTIK cytotoxicity mainly due to guanine alkylation, cytotoxic damage, which develops later, is launching a recovery mechanism for aberrant methyl balance. Nitrozosechovyny derivation. Dosing and Administration of drugs: for adults - patients who previously held chemotherapy, prescribed to be taken internally dose of 200 promenade / m 2 1 p / day for 5 days, 28-day cycle to patients previously treated with chemotherapy, the starting dose is 150 mg / m2 1 p / promenade in the second cycle, the dose may be increased to 200 mh/m2/dobu if the promenade day of the next cycle, the absolute number promenade neutrophils is <1,5 x109 to 1 liter, and the number of platelets is <100 x109 1 l Children: from promenade years to be taken internally dose of 200 mg / m 2 1 p / day for 5 days, 28-day cycle for children who previously treated with chemotherapy, the starting dose is 150 mg / m 2 1 p / day for 5 days increased to 200 promenade during the next cycle (if not marked signs of hematological toxicity, treatment continues until disease progression (maximum 2 years). Indications for use drugs: Hodgkin's disease, some forms of non-Hodgkin's lymphoma, leukemia hr.limfotsytarnyy, makrohlobulinemiya Valdenstrema. Indications for use drugs: malignant glioma in the form of multiple anaplastic astrocytoma or glioblastoma, in the presence of relapse or disease progression after standard therapy, the first line treatment of patients suffering from metastatic malignant melanoma widespread. Contraindications Serum Creatinine the use of drugs: hypersensitivity Familial Adenomatous Polyposis the drug. 5 mg, 20 mg, 100 mg, 250 mg. Contraindications to promenade use of drugs: hypersensitivity to the drug or dakarbazynu; signs expressed miyelosupresiyi, pregnant and nursing mothers. should be dissolved in 4 ml solvent is added, and shake for 2 minutes to get to Mr - Mr ready has a volume of 4.16 ml (200 mg in 4 ml fotemustynu district) got to Mr diluted at least 250 ml 5% isotonic glucose district for at / in writing (at DM 0.9% sol of sodium chloride); Mr injected i / v drip for 1 hour, not recommended for patients who received chemotherapy preceding 4 weeks (or 6 weeks if prior treatment drugs nitrozosechovyny) treatment promenade or supportive) can start, if the number here platelets? 100h109 / l and granulocytes? 2h109 / l, control blood test before each use, dosage should be chosen according to the hematological status of the patient, between the start of induction treatment and early supportive treatment ommended interval 8 weeks between cycles supporting treatment - 3 Cardiocerebral Resuscitation during and after induction treatment is recommended to monitor liver function; usual recommended dose is 100 mg/m2, in Induction monotherapy treatment: 3 consecutive infusions at intervals of 1 week followed by a period of calm therapeutic 4 - 5 weeks, supportive treatment: an infusion every 3 weeks (in combinations of chemotherapy third infusion abolished here induction treatment), dosage - at As much as you like mg/m2 ; use in children is examined. Preparations of drugs: powder for Mr promenade kit with solvent. Preparations of drugs: cap. Contraindications to the use of drugs: Considering the gravity readings absolute contraindications no promenade . Method of production of drugs: Table., Coated tablets, 2 mg powder for injection, Mr 50 mg with solvent in the amp. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic drug action, an effect which was related to abuse of DNA replication, in therapeutic doses affects more lymphoid tissue than in granulocytes, may cause irreversible miyelosupresiyu.