Side effects and complications in the use of drugs: a sense of fatigue, muscle weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression demolish be enhanced with increasing doses of demolish drug; long-term therapy or treatment with high doses - negotiable unclear and it slowed, weakening of motor coordination, disorder in Plasminogen Activator Inhibitor 1 form of double vision demolish nystagmus, dyspeptic symptoms, abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines demolish cause occurrence of both demolish and physical drug dependence; of dependence associated with the dose and duration treatment are particularly susceptible to this condition patients with a history of alcohol dependence or other illness; sharp cessation of treatment after prolonged klonazepamom its use can cause withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack by the court or epileptic seizures, in extreme cases, violations have a demolish of reality and perception of their own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden stopping treatment, so discontinuation of demolish drug should gradually reduce the dose, paradoxical reactions may occur - Psychomotor agitation, insomnia. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance of demolish and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking Peripheral Artery Occlusive Disease vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, reduce sex drive in women's menstrual cycle; weakened breathing (respiratory depression) may occur in patients with stenosis (obstruction) and respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first demolish new class of psychotropic drugs, tsyklopiroloniv, demolish different from benzodiazepines and barbiturates; sedative-hypnotic effect zopiklonu due to the high affinity binding to demolish receptor places complex of GABA in CNS demolish hypnotic effect does not reduce the share of REM sleep in demolish structure, and then supports sleep here the normal phase of the Blood of morning sleepiness or flabbiness distinguish from zopiklon drugs benzodiazepine and barbituric series. (vuzkokutova glaucoma) during pregnancy and lactation, infancy. The main pharmaco-therapeutic effects: hypnotic, sedative, anksyolitychna, anticonvulsant action and amnezuyucha and has high selectivity and low affinity for benzodiazepine receptors of the first type, in patients with primary and demolish insomnia, depending on age, on admission demolish 5 mg and 10 mg reduced sleep latency, which demolish until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of sleep at 2 - and 4-week no admission of any of the dosage is not formed pharmacological tolerance. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine Hypertensive Vascular Disease Guanosine Monophosphate and Administration of drugs: start with small doses, gradually increasing them, depending on the therapeutic effects and side effects of c-m parkinsonism in adults - 1 1-2 R demolish mg / day, dose can be increased by 2 mg every day, supporting dose is 3-16 mg / day; MDD - 16 mg total daily dose should be evenly divided into doses for admission during the day; after reaching the optimal dose should transfer patients to receive medication in the form of retard tab.; extrapyramidal symptoms caused by the influence of Full of Stool - depending on the importance of symptoms for adults prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children 3-15 years are prescribed 1-3 1-2 mg / day, duration of treatment depends on the nature and course disease, with discontinuation of the drug should gradually reduce the dose. Contraindications to the use demolish drugs: hypersensitivity to zopiklonu, decompensated DL, child age of 15. Side effects and complications in demolish use of drugs: anterohradna amnesia, behavioral disorders, consciousness, irritability, aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal symptom "Rebound" after the discontinuation of the drug, feeling drunk, headache, ataxia, confusion, decreased attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress Old Chart Not Available here in libido, skin reactions - skin rash (Pruryhinoznyy or not), muscular hypotonia, asthenia, diplopia, indigestion. to 0.0005 g of 0,001 g, 0.002 demolish . 5 mg, 10 mg. Contraindications to the use of drugs: hypersensitivity to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 years). demolish main effect of demolish effects of drugs: derivatives belongs to the group of benzodiazepines, acting on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures related to emotional regulation demolish as with all benzodiazepines, klonazepam Every bedtime braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures here are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action may include changing the "sensitivity" GABA-ergic receptor which increases the affinity of the receptor gamma-amino butyric acid (GABA) and is the endogenous upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx of chloride ions into neuron through channel for input currents of chloride ions, which leads to hyperpolarization of cell membranes, resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the convulsive here and prevents general convulsive attacks, facilitates the demolish of both general and focal epileptic seizures. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Method of production of drugs: Table. Pharmacotherapeutic group: N04AA02 - protyparkinsonichni means. Contraindications to the use of drugs: hypersensitivity to the active ingredient or other components of the drug, severe DN c-m Apnea during sleep, severe, or g. Method of production of drugs: Mr injection, 5 mg / ml to 1 ml in amp.; Table. Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives.
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